Human peripheral blood includes hematopoietic stem and progenitor cells plus immunologic cells. Stem cells give rise to all the blood cell types in the myeloid (monocytes, macrophages, neutrophils, basophils, eosinophils, megakaryocytes, dendritic cells) and lymphoid (T cells, B cells, NK cells) lineages.
See More Information
Hematopoiesis is a hierarchically organized process in which a population of hematopoietic stem cells (HSCs) gives rise to all blood cell lineages. HSCs possess the ability to differentiate into all functional blood cells and self–renew. Through a series of lineage commitment steps, HSCs give rise to progeny that progressively lose self-renewal potential causing them to become more restricted in their differentiation capacity, generating multi-potential and lineage-committed progenitor cells, and ultimately mature functional circulating blood cells.
The capability of hematopoietic stem cells to self-renew and differentiate is fundamental for the formation and maintenance of life-long hematopoiesis.Hematopoietic stem cells are highly valuable for their ability to reconstitute the hematopoietic system when transplanted. This has enabled their use in the clinic to treat a variety of disorders including bone marrow failure, myeloproliferative disorders and other acquired or genetic disorders that affect blood cells.
Showing all 31 results
There are no products |